Accumulation of genetic alterations during human tumor progression

This study was designed to identify tumor suppressor genes whose inactivation is associated with the acquisition of metastatic ability in colorectal carcinoma. The results indicate that a specific subset of tumor suppressor genes is involved in metastasis of colorectal carcinoma. First, both the p53...

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Bibliographic Details
Published inGan to kagaku ryoho Vol. 20; no. 3; p. 321
Main Authors Yokota, J, Ookawa, K
Format Journal Article
LanguageJapanese
Published Japan 01.02.1993
Subjects
Chromosome Deletion
Chromosomes, Human, Pair 13
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 18
Colorectal Neoplasms - genetics
Colorectal Neoplasms - pathology
Genes, DCC
Genes, p53
Genes, Tumor Suppressor
Humans
Liver Neoplasms - secondary
Polymorphism, Restriction Fragment Length
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Summary:This study was designed to identify tumor suppressor genes whose inactivation is associated with the acquisition of metastatic ability in colorectal carcinoma. The results indicate that a specific subset of tumor suppressor genes is involved in metastasis of colorectal carcinoma. First, both the p53 and DCC genes were altered in 100% of liver metastases. Second, the incidence of loss of heterozygosity (LOH) at loci on chromosomes 13q, 14q, and 18q in liver metastases was higher than in primary tumors. Third, LOH or rearrangement not detected in the primary tumors was observed on chromosomes 13q, 14q and 18q in liver metastases from the same patients, while alterations on chromosome 17p were always detected in both lesions. These observations indicate that concordant inactivation of the p53 and DCC genes and inactivation of several tumor-suppressor genes, especially those on chromosomes 13q and 14q, play important roles in the acquisition of metastatic potential in colorectal carcinoma.
ISSN:0385-0684