Prostaglandin (PG) modulation of bradykinin-induced hyperalgesia and oedema in the guinea-pig paw--effects of PGD2, PGE2 and PGI2

The relative potencies of PGD2, PGE2 and PGI2 in potentiating bradykinin-induced hyperalgesia and oedema were determined in the paws of aspirin-treated guinea-pigs. PGE2 and to a lesser degree PGD2 but not PGI2, potentiated bradykinin-induced hyperalgesia, whereas PGD2, but not PGE2 or PGI2, potenti...

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Bibliographic Details
Published inAgents and actions. Supplements Vol. 32; p. 107
Main Authors Whelan, C J, Head, S A, Poll, C T, Coleman, R A
Format Journal Article
LanguageEnglish
Published Switzerland 1991
Subjects
Animals
Aspirin - pharmacology
Bradykinin - pharmacology
Dinoprostone - pharmacology
Edema - chemically induced
Edema - prevention & control
Epoprostenol - pharmacology
Female
Guinea Pigs
Pain - chemically induced
Pain - prevention & control
Prostaglandin D2 - pharmacology
Prostaglandins - pharmacology
Sensory Thresholds - drug effects
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Summary:The relative potencies of PGD2, PGE2 and PGI2 in potentiating bradykinin-induced hyperalgesia and oedema were determined in the paws of aspirin-treated guinea-pigs. PGE2 and to a lesser degree PGD2 but not PGI2, potentiated bradykinin-induced hyperalgesia, whereas PGD2, but not PGE2 or PGI2, potentiated oedema. These findings differ from those in other species, and possibly reflect interspecies differences in modulation of inflammatory reactions by prostanoids.
ISSN:0379-0363
DOI:10.1007/978-3-0348-7405-2_14