Role of gut hormones in irritable bowel syndrome

In irritable bowel syndrome (IBS), motility disturbances occur from the upper gastrointestinal tract to the distal colon, where regulatory peptides have a wide-spread distribution. Studies on basal and postprandial plasma levels of different gut hormones show that VIP, CCK, and motilin may be closel...

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Bibliographic Details
Published inNihon rinshō Vol. 50; no. 11; p. 2697
Main Authors Morise, K, Furusawa, A, Yamamoto, H, Saito, H
Format Journal Article
LanguageJapanese
Published Japan 01.11.1992
Subjects
Animals
Cholecystokinin - metabolism
Cholecystokinin - physiology
Colonic Diseases, Functional - metabolism
Colonic Diseases, Functional - physiopathology
Gastrointestinal Motility
Humans
Motilin - metabolism
Motilin - physiology
Neuropeptide Y - metabolism
Neuropeptide Y - physiology
Peptide YY
Peptides - metabolism
Peptides - physiology
Rats
Rats, Sprague-Dawley
Vasoactive Intestinal Peptide - metabolism
Vasoactive Intestinal Peptide - physiology
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Summary:In irritable bowel syndrome (IBS), motility disturbances occur from the upper gastrointestinal tract to the distal colon, where regulatory peptides have a wide-spread distribution. Studies on basal and postprandial plasma levels of different gut hormones show that VIP, CCK, and motilin may be closely related to the symptoms including abdominal pain, diarrhea and constipation. In addition, peptide YY and NPY have effects on absorption in the intestine, and some opioid peptides exert actions on colonic motility in IBS patients. Recent studies revealed that gall bladder in IBS has an abnormal sensitivity to CCK-8, indicating that IBS patients has an generalized abnormality of the smooth muscle of the digestive tract. Gut hormones, which act as hormones, neurotransmitters and neuromodulators depending on their releasing site, may therefore play an important role in IBS patients.
ISSN:0047-1852