The effect of short-term immunotherapy with Pollinex on anti-IgE and antigen-induced histamine release from sensitive human basophils

Anti-IgE and antigen-induced histamine release from basophils isolated from 30 atopic patients sensitive to grass pollen allergens was evaluated. The studies were made before and after short-term immunotherapy with glutaraldehyde-pollen-tyrosine adsorbate (Pollinex). It was shown, that after immunot...

Full description

Saved in:
Bibliographic Details
Published inArchivum Immunologiae et Therapiae Experimentalis Vol. 33; no. 6; p. 777
Main Authors Chyrek-Borowska, S, Kuczewska, B, Hofman, J, Szymański, W, Lukaszewicz, D
Format Journal Article
LanguageEnglish
Published Switzerland 1985
Subjects
Aldehydes - administration & dosage
Allergens - therapeutic use
Antibodies, Anti-Idiotypic - immunology
Antibodies, Anti-Idiotypic - pharmacology
Antigens, Plant - therapeutic use
Basophils - analysis
Basophils - drug effects
Basophils - immunology
Drug Combinations - administration & dosage
Drug Combinations - pharmacology
Glutaral - administration & dosage
Glutaral - pharmacology
Histamine - metabolism
Histocompatibility Antigens Class II - analysis
Humans
Immunity, Active
Immunoglobulin E - immunology
Immunoglobulin E - pharmacology
Immunotherapy
Injections, Intramuscular
Phytotherapy
Plant Extracts
Pollen - administration & dosage
Pollen - immunology
Pollen - pharmacology
Time Factors
Tyrosine - administration & dosage
Tyrosine - pharmacology
Online AccessGet more information

Cover

More Information
Summary:Anti-IgE and antigen-induced histamine release from basophils isolated from 30 atopic patients sensitive to grass pollen allergens was evaluated. The studies were made before and after short-term immunotherapy with glutaraldehyde-pollen-tyrosine adsorbate (Pollinex). It was shown, that after immunotherapy a significant drop in anti-IgE and specific antigen-induced histamine release from isolated basophils occurs. The investigations confirm that the diminution of the target cell sensitivity and releasability may be one of the effects of specific immunotherapy.
ISSN:0004-069X