Clinical study on prostate cancer initially presenting with disseminated intravascular coagulation syndrome

• Published in: Hinyokika kiyo. Acta urologica Japonica Vol. 44; no. 6; pp. 387 - 390
• Main Authors: Ohtake, N, Kurita, S, Fukabori, Y, Imai, K, Yamanaka, H, Nakata, S, Sato, J, Kurihara, J, Mashimo, M, Sekihara, T, Saruki, K, Kawashima, K, Takahashi, H, Tsuchiya, K, Okabe, K, Jimbo, S, Kurita, M
• Format: Journal Article
• Language: Japanese
• Published: Japan 01.06.1998
• Subjects: Adenocarcinoma - complications; Adenocarcinoma - diagnosis; Adenocarcinoma - secondary; Aged; Aged, 80 and over; Bone Neoplasms - secondary; Disseminated Intravascular Coagulation - etiology; Humans; Male; Middle Aged; Prognosis; Prostate-Specific Antigen - blood; Prostatic Neoplasms - complications; Prostatic Neoplasms - diagnosis; Prostatic Neoplasms - pathology
• ISSN: 0018-1994

We experienced five patients with prostate cancer with disseminated intravascular coagulation syndrome (DIC) at the first presentation at Gunma University Hospital and affiliated institutions between 1991 and 1997. Their average age was 68 years, average DIC score at the first presentation was 10 and prostate specific antigen (PSA) level was more than 700 ng/ml. All of them had multiple bone metastases. The therapy for DIC and hormonal therapy for prostate cancer were simultaneously started at the first presentation before prostate needle biopsy, but all patients died. The average number of days from the start of DIC to death was 685 days. The patients initially showed a good response to therapy, but their conditions soon aggravated. The prognosis was extremely poor, but some proper therapies lead to the prognosis which was equal to that of prostate cancer in Stage D2 without DIC.