Effective combination therapy using radiation and a daily low dose of cis-platinum for advanced oropharyngeal carcinoma in an elderly patient--report of a case

An 83-year-old male with advanced oropharyngeal carcinoma was treated with combined radiotherapy and a daily low dose of cis-platinum with excellent results. In the early part of the treatment, radiotherapy was delivered in fractions of 1.8 Gy/day (5 days/week) to a cumulative dose of 20 Gy, concomi...

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Bibliographic Details
Published inGan to kagaku ryoho Vol. 21; no. 1; p. 115
Main Authors Tamura, M, Miyashita, T, Ogiso, A, Kotani, A, Oguchi, M, Izuno, I
Format Journal Article
LanguageJapanese
Published Japan 01.01.1994
Subjects
Aged
Aged, 80 and over
Cisplatin - administration & dosage
Combined Modality Therapy
Drug Administration Schedule
Humans
Injections, Intravenous
Lymphatic Metastasis
Male
Oropharyngeal Neoplasms - diagnostic imaging
Oropharyngeal Neoplasms - drug therapy
Oropharyngeal Neoplasms - pathology
Radiography
Radiotherapy Dosage
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Summary:An 83-year-old male with advanced oropharyngeal carcinoma was treated with combined radiotherapy and a daily low dose of cis-platinum with excellent results. In the early part of the treatment, radiotherapy was delivered in fractions of 1.8 Gy/day (5 days/week) to a cumulative dose of 20 Gy, concomitantly with UFT (400 mg/day po), but the response was not adequate. Then, instead of UFT, a single intravenous injection of cis-platinum (5 mg) was administered within 30 min after each radiation session without intravenous hydration. The total dose of cis-platinum was 140 mg and that of radiation was 70 Gy. Moderate leukocytopenia and moderate mucositis/dermatitis were observed as side effects, but despite the lack of intravenous hydration no signs of renal toxicity were observed. Partial remission was attained by the end of the therapy, remnant lesions progressively diminished in size, and 4 months later all of them had completely disappeared on the computed tomogram. The prognosis is favorable, and neither recurrence nor metastasis has been found in the 14-month follow-up period since the lesions disappeared.
ISSN:0385-0684