Embryonal carcinoma in two cases of androgen insensitivity syndrome: clinical, endocrinological and pathological features

Embryonal carcinoma in two cases of complete androgen insensitivity syndrome (CAIS) is reported. In both cases gonadectomy carried out for prophylactic purposes led to the discovery of a localized embryonal carcinoma with areas of anaplastic seminoma in one case. In non-neoplastic tissue, gonad morp...

Full description

Saved in:
Bibliographic Details
Published inEuropean journal of gynaecological oncology Vol. 9; no. 6; p. 489
Main Authors Lecca, U, Parodo, G, Fiore, R, Martino, E
Format Journal Article
LanguageEnglish
Published Italy 1988
Subjects
Adolescent
Adult
Androgen-Insensitivity Syndrome - pathology
Androgen-Insensitivity Syndrome - physiopathology
Androgens - blood
Androgens - physiology
Follicle Stimulating Hormone - blood
Gonads - pathology
Gonads - physiopathology
Humans
Luteinizing Hormone - blood
Male
Syndrome
Teratoma - pathology
Teratoma - physiopathology
Online AccessGet more information

Cover

More Information
Summary:Embryonal carcinoma in two cases of complete androgen insensitivity syndrome (CAIS) is reported. In both cases gonadectomy carried out for prophylactic purposes led to the discovery of a localized embryonal carcinoma with areas of anaplastic seminoma in one case. In non-neoplastic tissue, gonad morphology in both cases was typical of AIS. Prevalently hypotrophic aspects, especially in the interstitial gland, were found in case 2. This may explain the different endocrine profile in the two cases before gonadectomy. Our study, aside from series of psycho-sexual problems, shows, according to all Authors, that the most serious complication is the high risk of malignancy after puberty in patients with AIS.
ISSN:0392-2936