Mapping of cerebral metabolism on cerebral disorders using multi-slice proton magnetic resonance spectroscopic imaging

Multi-slice proton magnetic resonance spectroscopic imaging(MRSI) was performed using a 1.5 T clinical MR apparatus. Normal volunteer and several kinds of cerebral disorders were examined using following parameters; Tr/Te = 2.3 s/280 ms, slice thickness/gap/slices = 15/3.5 mm/4, 32 phase encoding an...

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Bibliographic Details
Published inNihon rinshō Vol. 55; no. 7; p. 1779
Main Authors Tanaka, C, Ebisu, T, Umeda, M, Naruse, S
Format Journal Article
LanguageJapanese
Published Japan 01.07.1997
Subjects
Aspartic Acid - analogs & derivatives
Aspartic Acid - metabolism
Brain - metabolism
Brain Neoplasms - metabolism
Cerebral Infarction - metabolism
Choline - metabolism
Creatinine - metabolism
Humans
Lactates - metabolism
Magnetic Resonance Spectroscopy - methods
Protons
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Summary:Multi-slice proton magnetic resonance spectroscopic imaging(MRSI) was performed using a 1.5 T clinical MR apparatus. Normal volunteer and several kinds of cerebral disorders were examined using following parameters; Tr/Te = 2.3 s/280 ms, slice thickness/gap/slices = 15/3.5 mm/4, 32 phase encoding and 24 cm FOV. Every 4 slice images of NAA, Cr, Cho and Lip/Lac were obtained in about 34 minutes. In control cases, images of Cr and Cho showed very high intensity at cerebellum comparing with cerebrum. This means high concentration or changes of relaxation times of both Cr and Cho. In cerebral infarction and brain tumor, though NAA images showed no signal intensity, Cr and Cho images showed small iso-or mild high-signal intensity areas. These findings suggest neuronal loss and gliosis or tumor growth in the lesions. In conclusion, MRSI has extremely high potential to evaluate metabolism of brain and cerebral disorders.
ISSN:0047-1852