TNM classification of bone and soft tissue sarcomas

TNM classification of bone and soft tissue sarcomas was published by UICC in 1987. Histological grading (G) is an important factor in this classification, but the criteria of G categories are not so clear. In addition, lymph node metastasis is very rare in bone and soft tissue sarcoma. Therefore, pr...

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Bibliographic Details
Published inGan to kagaku ryoho Vol. 24; no. 8; p. 1035
Main Authors Fukuma, H, Beppu, Y, Yokoyama, R, Omiya, K
Format Journal Article
LanguageJapanese
Published Japan 01.06.1997
Subjects
Bone Neoplasms - classification
Bone Neoplasms - pathology
Humans
Lymphatic Metastasis
Osteosarcoma - classification
Osteosarcoma - pathology
Osteosarcoma - secondary
Sarcoma - classification
Sarcoma - pathology
Sarcoma - secondary
Soft Tissue Neoplasms - classification
Soft Tissue Neoplasms - pathology
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Summary:TNM classification of bone and soft tissue sarcomas was published by UICC in 1987. Histological grading (G) is an important factor in this classification, but the criteria of G categories are not so clear. In addition, lymph node metastasis is very rare in bone and soft tissue sarcoma. Therefore, prognostic factors are limited to T, M and G categories. Since correlation between the stage (UICC) and the survival rate was not found in patients with osteosarcoma, TNM classification (UICC) has not been used widely in the field of orthopedic oncology. The Musculoskeletal Tumor Committee of the Japanese Orthopaedic Association proposed another TNM classification of osteosarcoma based on multivariate analysis. T1 is less than 15 cm and T2 is 15 cm or larger in maximal diameter. N and M are same with the UICC criteria. Serum alkaline phosphatase level (A) is included in this classification in which A0 is less than the normal value x2.5, and A1 is the normal value x2.5 or more. G categories are separated into two groups according to the mitotic rate in a high power field (x200); G1 is assigned to the tumor with 0-9/1 HPF and G2 is assigned to those with 10 or more/1 HPF. Reclassification of osteosar-coma by this modified TNM system indicated that there was a correlation between the survival rate and the stage.
ISSN:0385-0684