Promoter recognition and transcription initiation in E. coli

Analysis of stability maps of sequences harbouring E. coli RNA polymerase promoters shows a characteristic splitting in homostable domains, despite the heterogeneity of the sequences. Correlation of stability maps with results from static approaches giving the contact points of the enzyme on promote...

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Bibliographic Details
Published inFolia biologica Vol. 30 Spec No; pp. 105 - 118
Main Authors Ehrlich, R, Marin, M, Larousse, A, Gabarro-Arpa, J, Schmitt, B, Reiss, C
Format Journal Article
LanguageEnglish
Published Czech Republic 1984
Subjects
Base Composition
Base Sequence
DNA, Bacterial
DNA-Directed RNA Polymerases - genetics
Drug Stability
Escherichia coli - genetics
Lac Operon
Mutation
Operon
Plasmids
Transcription, Genetic
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Summary:Analysis of stability maps of sequences harbouring E. coli RNA polymerase promoters shows a characteristic splitting in homostable domains, despite the heterogeneity of the sequences. Correlation of stability maps with results from static approaches giving the contact points of the enzyme on promoters and functional studies employing abortive initiation assay allow us to propose a general mechanism for recognition of promoters and transcription start.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0015-5500