Preparation of new [1,2,4]triazolo[4,3-b]pyridazines. Part 12: Studies in the field of pyridazine compounds

6-Substituted-[1,2,4]triazolo[4,3-b]pyridazine-3-methanol, -aldehyde, -nitrile, -chloromethyl and -aminomethyl derivatives of potential antihypertensive activity were synthesized. The reduction of methyl[1,2,4]triazolo[4,3-b] pyridazine-3-carboxylate by lithium aluminium hydride and potassium borohy...

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Bibliographic Details
Published inPharmazie Vol. 38; no. 6; p. 369
Main Authors Kosáry, J, Kasztreiner, E, Lázár, A, Sóti, M
Format Journal Article
LanguageEnglish
Published Germany 01.06.1983
Subjects
Animals
Antihypertensive Agents - chemical synthesis
Chemical Phenomena
Chemistry
Pyridazines - chemical synthesis
Pyridazines - pharmacology
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Summary:6-Substituted-[1,2,4]triazolo[4,3-b]pyridazine-3-methanol, -aldehyde, -nitrile, -chloromethyl and -aminomethyl derivatives of potential antihypertensive activity were synthesized. The reduction of methyl[1,2,4]triazolo[4,3-b] pyridazine-3-carboxylate by lithium aluminium hydride and potassium borohydride was examined. The new compounds failed to exhibit hypotensive or antihypertensive effect. Compound 2a was a minor metabolite of GYKI-11679 [7].
ISSN:0031-7144