Detection of chromosomal aberration using fluorescence in situ hybridization in DNA diploid colorectal carcinomas

• Published in: Gan to kagaku ryoho Vol. 20; no. 6; p. 759
• Main Authors: Jibiki, M, Tagawa, Y, Miyashita, K, Hara, S, Yasutake, T, Nakazaki, T, Obatake, M, Sawai, T, Morinaga, M, Akama, F
• Format: Journal Article
• Language: English; Japanese
• Published: Japan 01.04.1993
• Subjects: Chromosome Aberrations; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 17; Chromosomes, Human, Pair 7; Colorectal Neoplasms - genetics; DNA, Neoplasm - analysis; Female; Humans; In Situ Hybridization, Fluorescence; Male; Ploidies

Numerical aberrations of chromosomes can be detected by fluorescence in situ hybridization (FISH), using chromosome-specific probes. It is possible to observe this in solid tumors from which it is very difficult to obtain metaphase nuclei. The present study employed surgical specimens from 15 cases...