Nonsteroidal antiinflammatory agents. Part 21: optically active stereoisomers of p-trifluoromethylphenyl- and p-thioanisyl-biphenylyl- hydroxypropionic acids

The synthesis, diastereomeric separation, assignment to erythro- and threo-configuration by 1HNMR, and optical resolution of 3-(p-trifluoromethyl-phenyl)- and (p-thioanisyl)-2-biphenylyl-3-hydroxypropionic acids are described. The enantiomers were submitted to a preliminary assay to determine antiin...

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Bibliographic Details
Published inPharmazie Vol. 47; no. 3; p. 174
Main Authors Varoli, L, Burnelli, S, Guarnieri, A, Scapini, G, Andrisano, V, Lumachi, B
Format Journal Article
LanguageEnglish
Published Germany 01.03.1992
Subjects
Animals
Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Biphenyl Compounds - chemical synthesis
Biphenyl Compounds - pharmacology
Carrageenan
Edema - drug therapy
Edema - physiopathology
Hydroxy Acids - chemical synthesis
Hydroxy Acids - pharmacology
Magnetic Resonance Spectroscopy
Male
Molecular Conformation
Rats
Rats, Inbred Strains
Stereoisomerism
Structure-Activity Relationship
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Summary:The synthesis, diastereomeric separation, assignment to erythro- and threo-configuration by 1HNMR, and optical resolution of 3-(p-trifluoromethyl-phenyl)- and (p-thioanisyl)-2-biphenylyl-3-hydroxypropionic acids are described. The enantiomers were submitted to a preliminary assay to determine antiinflammatory activity.
ISSN:0031-7144