Histoenzymological and ultrastructural changes in rats following the administration of aminopyrine and nitrite (nitrosoaminopyrine)

Wistar male rats weighing 230-250 g were given 10 mg aminopyrine and 10 mg sodium nitrite daily, by gavage, for 20 days. The histological changes in the liver are of the cirrhotic type. The ultrastructural changes are dependent on the hepatocyte position in the hepatic structural changes are depende...

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Bibliographic Details
Published inIARC scientific publications no. 31; p. 803
Main Authors Rusu, M A, Preda, N, Graciun, C, Gadaleanu, V, Bucur, N
Format Journal Article
LanguageEnglish
Published France 1980
Subjects
Acid Phosphatase - metabolism
Adenosine Triphosphatases - metabolism
Aminopyrine - analogs & derivatives
Aminopyrine - pharmacology
Animals
Collagen - metabolism
Electron Transport Complex IV - metabolism
Glucose-6-Phosphatase - metabolism
Glutamate Dehydrogenase - metabolism
Histocytochemistry
L-Lactate Dehydrogenase - metabolism
Liver - drug effects
Liver - enzymology
Liver - ultrastructure
Male
Microscopy, Electron
Nitrites - pharmacology
Oxidoreductases - metabolism
Rats
Succinate Dehydrogenase - metabolism
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Summary:Wistar male rats weighing 230-250 g were given 10 mg aminopyrine and 10 mg sodium nitrite daily, by gavage, for 20 days. The histological changes in the liver are of the cirrhotic type. The ultrastructural changes are dependent on the hepatocyte position in the hepatic structural changes are dependent on the hepatocyte position in the hepatic lobule. Thus, in the perilobular area one finds hepatocytes with an increased volume and hypertrophic nuclei and nucleoli, mitochondriae swollen with dispersed cristae, decrease of the number of free ribosomes, glycogen depletion, GER decrease and SER development. In the centrolobular area, the most injured, there are necrotic changes with numerous cytolysosomal formations. The histoenzymological results show a decrease of LDH, SDH, CyOx, GtDH, StDH, ATP-ase and G6P activities. The activity of Ac.P on the contrary, is greater in the intoxicated rats, which correlates with the above-mentioned necrobiosis processes.
ISSN:0300-5038