Increased lymphocyte transformation by insulin induced hypoglycaemia in normal subjects

To study the effect of carbohydrate metabolism on lymphocyte reactivity, we performed phytohaemoagglutinin and pokeweed mitogen induced lymphocyte transformation after insulin induced hypoglycaemia in normal subjects. A statistically significant increase of PHA-LT and a slight increase of PKW-LT wer...

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Bibliographic Details
Published inJournal of clinical & laboratory immunology Vol. 1; no. 4; p. 351
Main Authors Iavicoli, M, Pozzilli, P, Di Mario, U
Format Journal Article
LanguageEnglish
Published Scotland 01.02.1979
Subjects
Adult
Blood Glucose
Female
Humans
Hypoglycemia - chemically induced
Insulin
Lymphocyte Activation
Male
Phytohemagglutinins - pharmacology
Pokeweed Mitogens - pharmacology
Rosette Formation
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Summary:To study the effect of carbohydrate metabolism on lymphocyte reactivity, we performed phytohaemoagglutinin and pokeweed mitogen induced lymphocyte transformation after insulin induced hypoglycaemia in normal subjects. A statistically significant increase of PHA-LT and a slight increase of PKW-LT were detected 30 minutes following insulin administration. These data suggest a stimulating effect of insulin induced hypoglycaemia on T lymphocyte reactivity and this finding has clinical importance in regard to the management of diabetic patients.
ISSN:0141-2760