The toxicity and antitumor activity of three individual fractions of lectins from Ricinus communis seeds

Lectins from Ricinus communis seeds (RCL) have been resolved into three electrophoretically distinct fractions (alpha-RCL, beta-RCL, psi-RCL) by ion exchange chromatography on Watman CM-32 cellulose. The toxicity to mice and antitumor activity against murine lymphoma NK/Ly of pure fractions were com...

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Bibliographic Details
Published inNeoplasma Vol. 24; no. 3; p. 341
Main Authors Lutsyk, M D, Lutsyk, A D, Kipiani, E K, Krupko, A E
Format Journal Article
LanguageEnglish
Published Slovakia 1977
Subjects
Animals
Antineoplastic Agents - therapeutic use
Antineoplastic Agents - toxicity
Lectins - administration & dosage
Lectins - therapeutic use
Lectins - toxicity
Lymphoma - drug therapy
Lymphoma - pathology
Mice
Neoplasms, Experimental - drug therapy
Neoplasms, Experimental - pathology
Plant Lectins
Seeds
Spleen - pathology
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Summary:Lectins from Ricinus communis seeds (RCL) have been resolved into three electrophoretically distinct fractions (alpha-RCL, beta-RCL, psi-RCL) by ion exchange chromatography on Watman CM-32 cellulose. The toxicity to mice and antitumor activity against murine lymphoma NK/Ly of pure fractions were compared. Optimal effect was achieved with alpha-RCL, Which possessed the lowest toxicity (1000 micron g/kg) and significant antitumor activity (63% inhibition of tumor growth).
ISSN:0028-2685