Hyperreninemia and hyperaldosteronism in sickle cell anemia

Fourteen patients with sickle cell anemia, ages 6 to 20 years, were studied while ingesting high- and low-sodium diets. Although none of the patients had excessive urinary loss of sodium, the majority had elevated plasma renin activities and aldosterone secretion rates. The PRA was higher in patient...

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Bibliographic Details
Published inThe Journal of pediatrics Vol. 95; no. 2; pp. 206 - 209
Main Authors Matustik, M C, Carpentieri, U, Corn, C, Meyer, 3rd, W J
Format Journal Article
LanguageEnglish
Published United States 01.08.1979
Subjects
Adolescent
Adult
Age Factors
Aldosterone - blood
Anemia, Sickle Cell - blood
Child
Diet
Diet, Sodium-Restricted
Electrolytes - blood
Humans
Hyperaldosteronism - blood
Male
Renin - blood
Sodium - metabolism
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Summary:Fourteen patients with sickle cell anemia, ages 6 to 20 years, were studied while ingesting high- and low-sodium diets. Although none of the patients had excessive urinary loss of sodium, the majority had elevated plasma renin activities and aldosterone secretion rates. The PRA was higher in patients over 10 years of age; ASR in patients receiving the high-sodium diet increased with age. Patients with sickle cell anemia appeared to compensate for urinary sodium loss between crises. The mechanism of this loss could be a defect in the function of either the distal tubule or the loop of Henle.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0022-3476
DOI:10.1016/S0022-3476(79)80654-X