Immune response to infectious bovine rhinotracheitis virus (IBRV) following natural infection or vaccination by intranasally or parenterally administered vaccines

Neutralizing antibody activity is present in serum and nasal secretions of cattle following IBR virulent virus challenge or intranasal vaccination with live, avirulent virus. Levels of nasal secretion antibody activity (NS-AA) are low and short-lived following initial exposure, but are considerably...

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Bibliographic Details
Published inDevelopments in biological standardization Vol. 28; p. 526
Main Author Todd, J D
Format Journal Article
LanguageEnglish
Published Switzerland 1975
Subjects
Administration, Intranasal
Animals
Antibodies, Viral
Cattle
Cattle Diseases - immunology
Herpesvirus 1, Bovine - immunology
Herpesvirus 1, Bovine - isolation & purification
Infectious Bovine Rhinotracheitis - immunology
Infectious Bovine Rhinotracheitis - microbiology
Injections, Intramuscular
Nasal Mucosa - immunology
Neutralization Tests
Vaccination
Vaccines, Attenuated - administration & dosage
Viral Vaccines - administration & dosage
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Summary:Neutralizing antibody activity is present in serum and nasal secretions of cattle following IBR virulent virus challenge or intranasal vaccination with live, avirulent virus. Levels of nasal secretion antibody activity (NS-AA) are low and short-lived following initial exposure, but are considerably enhanced following reexposure provided infection occurs. NS-AA has not been detected in calves following parenteral administration of live virus vaccine. Such calves are subject to infection by challenge virus administered intranasally as early as three weeks after vaccination. Unlike parenterally administered vaccine, vaccine administeredintranasally promotes active immunity in young calves born of immune dams. Calves so vaccinated respond to later challenge with rapid, pronounced increases in both serum antibody and NS-AA without displaying overt signs of disease. Avirulent virus administered intranasally promotes release of interferon into nasal secretions for a period of six to eight days, coincident with continued virus replication. Classes of immunoglobulin involved in the various responses will be discussed.
ISSN:0301-5149