Interlaboratory variability of valproic acid determinations

19 pooled plasma specimens were sent as unknowns to 13 participating research laboratories. The interlaboratory variability between the results was very high. Only 4 out of 13 laboratories had 6--12% of their results within the 95% confidence limit for each sample. The precision of repeated determin...

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Bibliographic Details
Published inArzneimittel-Forschung Vol. 27; no. 5; p. 1078
Main Authors Schmidt, D, Ferrandes, B, Grandjean, D, Gugler, R, Jakobs, C, Johannessen, S, Klotz, U, Kochen, W, Kupferberg, H J, Meijer, J W, Richens, A, Schäfer, H, Schulz, H U, Windorfer, A
Format Journal Article
LanguageEnglish
Published Germany 1977
Subjects
Laboratories - standards
Methods
Quality Control
Valerates - blood
Valproic Acid - blood
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Summary:19 pooled plasma specimens were sent as unknowns to 13 participating research laboratories. The interlaboratory variability between the results was very high. Only 4 out of 13 laboratories had 6--12% of their results within the 95% confidence limit for each sample. The precision of repeated determinations was fairly good. 6 out of 10 participating laboratories had a coefficient of variation of less then 5%. The reproducibility and the agreement between the different procedures for quantitative analysis of dipropylacetate is similar to that reported for other major antiepileptic drugs.
ISSN:0004-4172