Inhibitory effects of gabexate mesilate (FOY) on experimental DIC

The inhibitory effects of a newly synthesized protease inhibitor, Gabexate mesilate (FOY), on experimental disseminated intravascular coagulation were studied as compared with those of aprotinin or heparin. Thrombin, tissue thromboplastin, and endotoxin were used as DIC trigger substances. As parame...

Full description

Saved in:
Bibliographic Details
Published inAdvances in experimental medicine and biology Vol. 120B; p. 385
Main Author Isobe, J
Format Journal Article
LanguageEnglish
Published United States 1979
Subjects
Animals
Aprotinin - pharmacology
Blood Platelets - physiology
Disseminated Intravascular Coagulation - chemically induced
Disseminated Intravascular Coagulation - drug therapy
Endotoxins
Fibrinogen - analysis
Guanidines - therapeutic use
Heparin - pharmacology
Male
Mesylates - therapeutic use
Platelet Aggregation - drug effects
Protease Inhibitors - pharmacology
Protease Inhibitors - therapeutic use
Rabbits
Thrombin
Thromboplastin
Online AccessGet more information

Cover

More Information
Summary:The inhibitory effects of a newly synthesized protease inhibitor, Gabexate mesilate (FOY), on experimental disseminated intravascular coagulation were studied as compared with those of aprotinin or heparin. Thrombin, tissue thromboplastin, and endotoxin were used as DIC trigger substances. As parameters on DIC, platelet counts, white blood cell counts, neutrophilic leukocyte counts, fibrinogen, fibrin degradation products, platelet retention, platelet aggregation, prothrombin time, partial thromboplastin time were served. The drug efficacy in each parameter were expressed by the score system and analyzed statistically. The results were summarized as follows; (1) In thrombin-induced DIC, FOY was apparently superior to the other drugs (p less than 0.05). (2) In thromboplastin-induced DIC, heparin was slightly more effective than FOY or aprotinin. (3) In endotoxin infusion, there were no significant differences among them. In conclusion, the results of the present study suggest that FOY was more effective than heparin or aprotinin on experimental DIC.
ISSN:0065-2598