One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice

One hundred and twenty-seven cultured human tumor cell lines produced tumors after sc inoculation of 1-20 million cells into nude mice. They included 56 carcinoma lines, 14 sarcoma lines, and 57 lines from miscellaneous tumors and were all glucose-6-phosphate dehydrogenase type B. Twenty-nine percen...

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Bibliographic Details
Published inJNCI : Journal of the National Cancer Institute Vol. 59; no. 1; p. 221
Main Authors Fogh, J, Fogh, J M, Orfeo, T
Format Journal Article
LanguageEnglish
Published United States 01.07.1977
Subjects
Animals
Cell Line
Female
Glucosephosphate Dehydrogenase - analysis
HeLa Cells - enzymology
Humans
Isoenzymes - analysis
Male
Mice
Mice, Nude
Neoplasm Transplantation
Neoplasms - enzymology
Neoplasms - pathology
Transplantation, Heterologous
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Summary:One hundred and twenty-seven cultured human tumor cell lines produced tumors after sc inoculation of 1-20 million cells into nude mice. They included 56 carcinoma lines, 14 sarcoma lines, and 57 lines from miscellaneous tumors and were all glucose-6-phosphate dehydrogenase type B. Twenty-nine percent of the lines produced tumors of 1 cm3 size within 1 month and 41% in the second month after inoculation. The histopathology correlated with the human tumor of origin in all cases.
ISSN:0027-8874