Optomechanics reveals transmitter roles in neuromuscular junctions

Wingerd discusses the study by a team led by Paul Brehm at the Vollum Institute at Oregon Health and Science University in Portland OR on neuromuscular function. The study used a variety of microscopy techniques to investigate neuromuscular signaling in zebrafish embryos. The researchers combine ele...

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Bibliographic Details
Published inLaser focus world Vol. 55; no. 7; p. 35
Main Author Wingerd, John
Format Magazine Article
LanguageEnglish
Published Tulsa Endeavor Business Media 01.07.2019
Subjects
Brehm, Paul
Embryos
Fluorescence
Microscopy
Mutants
Neuromuscular diseases
Opto-mechanics
Zebrafish
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Summary:Wingerd discusses the study by a team led by Paul Brehm at the Vollum Institute at Oregon Health and Science University in Portland OR on neuromuscular function. The study used a variety of microscopy techniques to investigate neuromuscular signaling in zebrafish embryos. The researchers combine electrophysiological measurements with differential interference contrast (DIC) and fluorescence imaging, and sometimes optogenetics, in a microscope setup that depends on drift-free precision probe motion. By working with zebrafish mutants, they have correlated certain transmitter deficiencies with several identified human disorders.
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ISSN:1043-8092