Polymeric nanoparticles as dual-imaging probes for cancer management

This article reports the development of biodegradable photoluminescent polymer (BPLP)-based nanoparticles (NPs) incorporating either magnetic nanoparticles (BPLP-MNPs) or gadopentate dimeglumine (BPLP-Gd NPs), for cancer diagnosis and treatment. The aim of the study is to compare these nanoparticles...

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Published inBiomaterials and Biomechanics in Bioengineering Vol. 3; no. 3; pp. 129 - 140
Main Authors Menon, Jyothi U, Jadeja, Parth, Tambe, Pranjali, Thakore, Dheeraj, Zhang, Shanrong, Takahashi, Masaya, Xie, Zhiwei, Yang, Jian, Nguyen, Kytai T
Format Journal Article
LanguageEnglish
Published 01.09.2016
Subjects
Biodegradability
Biomechanics
Biomedical materials
Cancer
Nanoparticles
Photoluminescence
Surface properties
Surgical implants
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Summary:This article reports the development of biodegradable photoluminescent polymer (BPLP)-based nanoparticles (NPs) incorporating either magnetic nanoparticles (BPLP-MNPs) or gadopentate dimeglumine (BPLP-Gd NPs), for cancer diagnosis and treatment. The aim of the study is to compare these nanoparticles in terms of their surface properties, fluorescence intensities, MR imaging capabilities, and in vitro characteristics to choose the most promising dual-imaging nanoprobe. Results indicate that BPLP-MNPs and BPLP-Gd NPs had a size of 195
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ISSN:2465-9835
2465-9959
DOI:10.12989/bme.2016.3.3.129