Association between TNF- alpha -308G>A and -238G>A gene polymorphisms and TNF- alpha serum levels in Mexican colorectal cancer patients

• Published in: Genetics and molecular research Vol. 15; no. 2
• Main Authors: Gutierrez-Hurtado, I A, Puebla-Perez, A M, Delgado-Saucedo, J I, Figuera, L E, Zuniga-Gonzalez, G M, Gomez-Mariscal, K, Ronquillo-Carreon, C A, Gallegos-Arreola, M P
• Format: Journal Article
• Language: English
• Published: 01.01.2016
• ISSN: 1676-5680; 1676-5680
• DOI: 10.4238/gmr.15028199

The objective of this study was to examine the association between TNF- alpha serum levels and -308G>A and -238G>A polymorphisms in the corresponding gene by comparing healthy subjects to colorectal cancer (CRC) patients from a Mexican population. Serum levels of TNF- alpha were found to significantly differ between CRC patients and controls (P = 0.001), but no relationship between the -308G>A and -238G>A polymorphisms and increased CRC risk was established (P > 0.05). However, an association between the -308G>A variant and disease became evident when the distribution of AA-GA genotypes was examined in patients with hematologic toxicity (neutropenia) and those without (odds ratio = 3.356, 95% confidence interval = 1.295- 8.698, P = 0.013). The GG haplotype was more common in controls than CRC patients, with a frequency of 0.85 among the former, but this difference was not significant (P > 0.05). In conclusion, TNF- alpha serum levels and AA-AG genotypes of the TNF- alpha -308G>A polymorphism may significantly contribute to CRC susceptibility in the population examined in this investigation.