ANTIOXIDANT, CYTOTOXIC AND ANTIMICROBIAL ACTIVITY OF SONNERATIA ALBA BARK

The present study was undertaken to evaluate antioxidant, cytotoxic and antimicrobial activity of Sonneratia alba bark. The carbon tetrachloride, chloroform soluble partitionate of methanolic extract and crude methanolic extract showed significant antioxidant property using 1,1-diphenyl-2-pecrylhydr...

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Bibliographic Details
Published inInternational journal of pharmaceutical sciences and research Vol. 3; no. 7; p. 2233
Main Authors Milon, Md Ali, Muhit, Md Abdul, Goshwami, Durajan, Masud, Mohammad Mehedi, Begum, Bilkis
Format Journal Article
LanguageEnglish
Published 01.07.2012
Subjects
Bacillus cereus
Bacillus subtilis
Pseudomonas aeruginosa
Sarcina
Shigella dysenteriae
Sonneratia alba
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Summary:The present study was undertaken to evaluate antioxidant, cytotoxic and antimicrobial activity of Sonneratia alba bark. The carbon tetrachloride, chloroform soluble partitionate of methanolic extract and crude methanolic extract showed significant antioxidant property using 1,1-diphenyl-2-pecrylhydrazyl(DPPH) scavenging assay ,of which chloroform partitionate and crude extract demonstrated highest activity with IC sub( 50) value of 12 mu g/ml and 14 mu g/ml respectively. In the brine shrimp lethality bioassay, LC sub( 50) values obtained from the best fit line slope were 0.812, 14.94, 0.831 and 3.288 mu g/ml for standard (Vincristine sulphate), n-Hexane, carbon tetrachloride and chloroform soluble partitionate of methanolic extract respectively. The carbon tetrachloride soluble fraction revealed moderate activities against Bacillus cereus, Bacillus subtilis, Sarcina lutea, Pseudomonas aeruginosa and Shigella dysenteriae test organisms.
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ISSN:0975-8232
DOI:10.13040/IJPSR.0975-8232.3(7).2233-37