Involvement of alpha 7 nAChR subtype in rat oxaliplatin-induced neuropathy: Effects of selective activation

Oxaliplatin, unlike other platinum anticancer agents, has only mild toxic effects on the hematopoietic, urinary and gastrointestinal systems. Its dose-limiting side effect is neurotoxicity that may evolve to a neuropathic syndrome which is difficult to treat.

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Bibliographic Details
Published inNeuropharmacology Vol. 79; pp. 37 - 48
Main Authors Mannelli, Lorenzo Di Cesare, Pacini, Alessandra, Matera, Carlo, Zanardelli, Matteo, Mello, Tommaso, Amici, Marco De, Dallanoce, Clelia, Ghelardini, Carla
Format Journal Article
LanguageEnglish
Published 01.04.2014
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Summary:Oxaliplatin, unlike other platinum anticancer agents, has only mild toxic effects on the hematopoietic, urinary and gastrointestinal systems. Its dose-limiting side effect is neurotoxicity that may evolve to a neuropathic syndrome which is difficult to treat.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ISSN:0028-3908
DOI:10.1016/j.neuropharm.2013.10.034