RESPONSES OR EFFECT OF CEREBRAL MALARIA ON PLATELET COUNT, PLATELET FACTOR - 3 AND PLATELET AGGREGATE AVAILABILITY IN CHILDREN

Malaria, a formidable global parasitic infection represent a major health problem in tropical countries in terms of geographical spread, high morbidity, severe mortality especially among children. This study investigated platelet function's role and its strength to make platelet factor 3 (PF-3)...

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Published inInternational journal of pharmaceutical sciences and research Vol. 2; no. 12; p. 3096
Main Authors Ogboi, S J, Akpalu, S P, Joshua, I A, Agu, P U
Format Journal Article
LanguageEnglish
Published 01.12.2011
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Summary:Malaria, a formidable global parasitic infection represent a major health problem in tropical countries in terms of geographical spread, high morbidity, severe mortality especially among children. This study investigated platelet function's role and its strength to make platelet factor 3 (PF-3) available for coagulation in children with cerebral malaria. Packed cell volume, platelet aggregate, platelet count and platelet factor-3 were studied in 65 children with, cerebral malaria and 50 healthy control children (Both group were aged 1-9 years). Packed cell volume, platelet count were significantly lower (P<0.01) in children with malaria and platelet factor-3 was significantly higher (P<0.01) in children with cerebral malaria compared to normal children (controls). There was no significant level of platelet aggregate between children with cerebral malaria and control.
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ISSN:0975-8232
DOI:10.13040/IJPSR.0975-8232.2(12).3096-99