TOXICOLOGICAL CHRACTERIZATION OF BRHANMANJISTHADI KVATHA CURNA (BRH) ON THE BASIS OF TOTAL PROTEIN AND ALBUMIN CONTENT, LIPID PROFILE, LIVER FUNCTION, KIDNEY FUNCTION, SERUM URIC ACID AND ENZYMATIC PROPERTY IN RATS' PLASMA AFTER CHRONIC ADMINISTRATION

• Published in: International journal of pharmaceutical sciences and research Vol. 7; no. 3; p. 991
• Main Authors: Arif, Sadique Mohammad, Huque, Amdadul, Abdullah-Al-Mamun, Md, Ahmed, S M Ahsan Uddin, Ali, Md Omar
• Format: Journal Article
• Language: English
• Published: 01.03.2016
• ISSN: 0975-8232
• DOI: 10.13040/IJPSR.0975-8232.7(3).991-04

Brhanmanjisthadi Kvatha Curna (BRH) an Ayurvedic preparation, is used as a traditional medicine in filariasis in the northern part of the country. After 45 consecutive days of chronic administration of the BRH preparation in rats its toxicological aspects was studied. In this study the total protein content in the plasma was increased (2.80%) in BRH treated male rats in comparison to their control male groups. The result showed no significant difference between the control and the BRH treated groups, yet the increase was noticeable (p=0.072). But the albumin content was significantly (p<0.001) increased (17.11 %) in BRH treated male rats & the increase was statistically very highly significant. In the female rats group the total protein (6.80 %) and the albumin content in the plasma were also increased in comparison to their control groups. A statistically very highly significant (p<0.001) increase was noted (15.09 %) only in the case of albumin.