Selective cytotoxicity and luminescence imaging of cancer cells with a dipicolinato-based EuIII complex

Four new species [Ln(dipicNH2)3]3- (Ln = LaIII, EuIII, GdIII, TbIII), with the ligand dipicNH22- (dipic = dipicolinato), were synthesized. Incubation of the EuIII complex with glioma NG97 and pancreatic cancer PANC1 cells showed that it penetrates the cell membrane and can be used to image the cells...

Full description

Saved in:
Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 53; no. 86; pp. 11818 - 11821
Main Authors Monteiro, J H S K, Machado, D, de Hollanda, L M, Lancellotti, M, Sigoli, F A, de Bettencourt-Dias, A
Format Journal Article
LanguageEnglish
Published 07.11.2017
Online AccessGet full text

Cover

More Information
Summary:Four new species [Ln(dipicNH2)3]3- (Ln = LaIII, EuIII, GdIII, TbIII), with the ligand dipicNH22- (dipic = dipicolinato), were synthesized. Incubation of the EuIII complex with glioma NG97 and pancreatic cancer PANC1 cells showed that it penetrates the cell membrane and can be used to image the cells, while also being moderately cytotoxic.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1364-548X
DOI:10.1039/c7cc06753d