Effect of transforming growth factor- beta 1 on interleukin-6 secretion in human myoblasts

Transforming growth factor- beta (TGF- beta ) is involved in several autoimmune neurological diseases. It is still unclear whether its local action can be pro-inflammatory or anti-inflammatory in the muscle tissue, because of the few reports on this subject. We have previously shown that human myobl...

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Published inJournal of neuroimmunology Vol. 87; no. 1-2; pp. 185 - 188
Main Authors Mazzarelli, P, Scuderi, F, Mistretta, G, Provenzano, C, Bartoccioni, E
Format Journal Article
LanguageEnglish
Published 01.07.1998
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Summary:Transforming growth factor- beta (TGF- beta ) is involved in several autoimmune neurological diseases. It is still unclear whether its local action can be pro-inflammatory or anti-inflammatory in the muscle tissue, because of the few reports on this subject. We have previously shown that human myoblasts secrete interleukin-6 (IL-6) when stimulated with inflammatory cytokine such as interleukin-1 beta (IL-1 beta ) or tumor necrosis factor alpha . In the present report, we show that TGF- beta 1 can induce IL-6 production; moreover, costimulation or short term pre-incubation with TGF- beta 1 increases IL-1 beta effect, while a longer incubation inhibits its action.
Bibliography:ObjectType-Article-2
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ISSN:0165-5728
DOI:10.1016/S0165-5728(98)00110-6