Reduced Risk of AIDS Lymphoma in Individuals Heterozygous for the CCR5- Delta 32 Mutation

• Published in: Cancer research (Chicago, Ill.) Vol. 59; no. 15; pp. 3561 - 3564
• Main Authors: Dean, M, Jacobson, L P, McFarlane, G, Margolick, J B, Jenkins, F J, Howard, OMZ, Dong, H-F, Goedert, J J, Buchbinder, S, Gomperts, E, Vlahov, D, Oppenheim, J J, O'Brien, S J, Carrington, M
• Format: Journal Article
• Language: English
• Published: 01.08.1999
• ISSN: 0008-5472

Non-Hodgkin's lymphoma (NHL) has been increasing in frequency in the industrialized world, but the environmental and genetic factors that contribute to susceptibility are not known. B-cell lymphomas represent a major cause of morbidity and mortality in HIV-infected individuals. The identification of a deletion in the CCR5 chemokine receptor gene that alters the risk for infection and progression to AIDS led us to examine a potential role of this gene in AIDS lymphoma. A matched case-control analysis was performed using all eligible NHL cases in the Multicenter AIDS Cohort Study. Patients were matched for age, study center, time AIDS-free, and slope of the CD4+ T-cell decline. The CCR5- Delta 32 allele was found to be associated with a 3-fold lower risk of NHL among individuals after controlling for time of infection and progression toward AIDS. The CCR5 gene was not associated with a difference in risk for Kaposi's sarcoma, another common malignancy in AIDS patients, or opportunistic infections. Costimulation of normal phorbol 12-myristate 13-acetate-treated B cells with the CCR5 ligand RANTES induced a proliferative response, indicating that RANTES is a mitogen for B cells. Taken together, these findings suggest that the CCR5 gene plays a role in the risk of NHL in HIV-infected patients, perhaps through a mechanism involving a decreased response of B cells to the mitogenic activity of RANTES.