Effects of recombinant IL-4 delta 2 on human peripheral blood mononuclears

In human cells, expression of IL-4 gene involves alternative mRNA splicing. IL-4 delta 2 splice variant is an antagonist of full-length IL-4 protein and blocks its effect on the functional activity of immunocompetent cells. The effect of recombinant IL-4 delta 2 on cytokine-producing activity of hum...

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Published inBulletin of experimental biology and medicine Vol. 143; no. 1; pp. 72 - 74
Main Authors Silkov, AN, Gavrilenko, V A, Denisova, V V, Grishina, LV, Kozlov, V A, Sennikov, S V
Format Journal Article
LanguageEnglish
Published 01.01.2007
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Summary:In human cells, expression of IL-4 gene involves alternative mRNA splicing. IL-4 delta 2 splice variant is an antagonist of full-length IL-4 protein and blocks its effect on the functional activity of immunocompetent cells. The effect of recombinant IL-4 delta 2 on cytokine-producing activity of human peripheral blood mononuclear cells is shown for the first time.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-007-0020-3