Uncoupling Protein 3 and Peroxisome Proliferator-Activated Receptor gamma 2 Contribute to Obesity and Diabetes in Palauans

• Published in: Biochemical and biophysical research communications Vol. 281; no. 3; pp. 772 - 778
• Main Authors: Yanagisawa, Y, Hasegawa, K, Dever, G J, Otto, C T, Sakuma, M, Shibata, S, Miyagi, S, Kaneko, Y, Kagawa, Y
• Format: Journal Article
• Language: English
• Published: 02.03.2001
• Subjects: b3-adrenergic receptors; peroxisome proliferator-activated receptors; uncoupling protein 3
• ISSN: 0006-291X
• DOI: 10.1006/bbrc.2001.4417

We examined the genetic contribution of single nucleotide polymorphisms (SNPs) of the energy metabolism-related genes, including beta 3 adrenergic receptor ( beta 3AR), apolipoprotein E (apo-E), promoter of uncoupling protein 3 (UCP3-p), peroxisome proliferator-activated receptor gamma 2 (PPAR gamma 2) and leptin receptor (LEPR) to metabolic disorders, in 118 inhabitants of Palau. The data were statistically analyzed and ethnically compared to correlate SNPs and their metabolic parameters. UCP3-p (P < 0.01) and PPAR gamma 2 (p = 0.05) correlated with plasma HbA1c, and UCP3-p correlated with fasting blood glucose (P < 0.01) in males, but not in females. UCP3-p correlated with body fat (%) (P < 0.01) in females, but not in males. Plasma leptin levels and apo-E were correlated in both groups. The frequency of SNPs for PPAR gamma 2, LEPR, and UCP3-p are significantly different between Palauans and Caucasians. Copyright 2001 Academic Press.