Modulation of inflammation through IL-17 production by gamma delta T cells: Mandatory in the mouse, dispensable in humans?

Recent studies suggest that gamma delta T cells are innate IL-17 producers owing to unique features of their developmental program. A key contribution of this subset to T helper 17 responses has been also suggested by numerous physiopathological studies mainly performed in mouse models. In the prese...

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Bibliographic Details
Published inImmunology letters Vol. 127; no. 1; pp. 8 - 12
Main Authors Deknuydt, F, Scotet, E, Bonneville, M
Format Journal Article
LanguageEnglish
Published 02.12.2009
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Summary:Recent studies suggest that gamma delta T cells are innate IL-17 producers owing to unique features of their developmental program. A key contribution of this subset to T helper 17 responses has been also suggested by numerous physiopathological studies mainly performed in mouse models. In the present review, we will summarize the main features of IL-17-producing gamma delta T cells and highlight the similarities and differences between murine gamma delta T cells and their human counterparts.
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ISSN:0165-2478
DOI:10.1016/j.imlet.2009.08.003