Non-peptide antigens activating human V gamma 9/V delta 2 T lymphocytes

Various non-peptidic ligands which specifically activate most of circulating human V gamma 9/V delta 2 T lymphocytes are now known. Most of these are so-called phosphoantigens and directly trigger the V gamma 9 /V delta 2 TCR expressing cells, without need for MHC-restricted presentation molecules....

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Bibliographic Details
Published inImmunology letters Vol. 95; no. 2; pp. 129 - 138
Main Authors Poupot, M, Fournie, J-J
Format Journal Article
LanguageEnglish
Published 01.09.2004
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Summary:Various non-peptidic ligands which specifically activate most of circulating human V gamma 9/V delta 2 T lymphocytes are now known. Most of these are so-called phosphoantigens and directly trigger the V gamma 9 /V delta 2 TCR expressing cells, without need for MHC-restricted presentation molecules. Although some potent phosphoantigens currently involved in clinical trials are chemically-synthesized molecules, most of the natural antigens were isolated from microbial cultures. The structures and biosynthesis of phosphoantigens are reviewed here and the possible physiological significance of their recognition by gamma delta T lymphocytes is discussed.
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ISSN:0165-2478
DOI:10.1016/j.imlet.2004.06.013