Robust gamma delta T cell expansion in infants immunized at birth with BCG vaccine
Cell-mediated immune responses to BCG vaccine were evaluated in 7-month-old infants vaccinated with intradermal combined BCG and Hepatitis B or intradermal BCG and intramuscular Hepatitis B at birth. Peripheral blood mononuclear cell cultures from both groups showed CD4+, CD8+ and remarkable gamma d...
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| Published in | Vaccine Vol. 25; no. 34; pp. 6313 - 6320 |
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| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
21.08.2007
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| Online Access | Get full text |
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| Abstract | Cell-mediated immune responses to BCG vaccine were evaluated in 7-month-old infants vaccinated with intradermal combined BCG and Hepatitis B or intradermal BCG and intramuscular Hepatitis B at birth. Peripheral blood mononuclear cell cultures from both groups showed CD4+, CD8+ and remarkable gamma delta + T cell BCG-specific proliferation, without significant differences. Also, IL-10, IL-12, IFN- gamma and TNF- alpha concentrations in culture supernatants, measured by ELISA, were similar. The results suggested that the combined BCG and Hepatitis B vaccine was as immunogenic as BCG separated from Hepatitis B vaccine. |
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| AbstractList | Cell-mediated immune responses to BCG vaccine were evaluated in 7-month-old infants vaccinated with intradermal combined BCG and Hepatitis B or intradermal BCG and intramuscular Hepatitis B at birth. Peripheral blood mononuclear cell cultures from both groups showed CD4+, CD8+ and remarkable gamma delta + T cell BCG-specific proliferation, without significant differences. Also, IL-10, IL-12, IFN- gamma and TNF- alpha concentrations in culture supernatants, measured by ELISA, were similar. The results suggested that the combined BCG and Hepatitis B vaccine was as immunogenic as BCG separated from Hepatitis B vaccine. |
| Author | Netto, A Aranha Morcillo, A M Mazzola, T N Da Silva, M T N Raw, I Carniel, E F Vilela, M M S Lima, S C B S Zanolli, M L Moreno, Y M F Blotta, M H |
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