Robust gamma delta T cell expansion in infants immunized at birth with BCG vaccine

Cell-mediated immune responses to BCG vaccine were evaluated in 7-month-old infants vaccinated with intradermal combined BCG and Hepatitis B or intradermal BCG and intramuscular Hepatitis B at birth. Peripheral blood mononuclear cell cultures from both groups showed CD4+, CD8+ and remarkable gamma d...

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Published inVaccine Vol. 25; no. 34; pp. 6313 - 6320
Main Authors Mazzola, T N, Da Silva, M T N, Moreno, Y M F, Lima, S C B S, Carniel, E F, Morcillo, A M, Zanolli, M L, Netto, A Aranha, Blotta, M H, Raw, I, Vilela, M M S
Format Journal Article
LanguageEnglish
Published 21.08.2007
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Summary:Cell-mediated immune responses to BCG vaccine were evaluated in 7-month-old infants vaccinated with intradermal combined BCG and Hepatitis B or intradermal BCG and intramuscular Hepatitis B at birth. Peripheral blood mononuclear cell cultures from both groups showed CD4+, CD8+ and remarkable gamma delta + T cell BCG-specific proliferation, without significant differences. Also, IL-10, IL-12, IFN- gamma and TNF- alpha concentrations in culture supernatants, measured by ELISA, were similar. The results suggested that the combined BCG and Hepatitis B vaccine was as immunogenic as BCG separated from Hepatitis B vaccine.
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ISSN:0264-410X
DOI:10.1016/j.vaccine.2007.06.039