A Novel Limonoid from the Seeds of Chisocheton macrophyllus

This study aimed to isolatea novel limonoid compound, (6R,7S, 8R, 9R, 10R, 11R, 13S, 17R)-17-(furan-3-yl) -4, 4, 8, 10, 13-pentamethyl-3-oxo-4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 16, 17-dodecahydro-3H-cyclopenta[a]phenanthrene-6,7,11-triyltriacetate (11α-acetoxydysobinin) (1), and 3 pre-existing limonoi...

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Bibliographic Details
Published inRecords of natural products Vol. 18; no. 3; p. 351
Main Authors Nurlelasari, Huda, Muhammad, Safriansyah, Wahyu, Supratman, Unang, Budiman, Yudha, Desi Harneti P. Huspa, Maharani, Rani, Mayanti, Tri, Farabi, Kindi, Fajriah, Sofa
Format Journal Article
LanguageEnglish
Published Gebze ACG Publications 01.05.2024
Subjects
Breast cancer
Chemical compounds
Cytotoxicity
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Summary:This study aimed to isolatea novel limonoid compound, (6R,7S, 8R, 9R, 10R, 11R, 13S, 17R)-17-(furan-3-yl) -4, 4, 8, 10, 13-pentamethyl-3-oxo-4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 16, 17-dodecahydro-3H-cyclopenta[a]phenanthrene-6,7,11-triyltriacetate (11α-acetoxydysobinin) (1), and 3 pre-existing limonoids, namely dysobinin (2), dysobinol (3), and 7-deacetylepoxyazadiradione (4) from the seeds of Chisocheton macrophyllus (Meliaceae). In addition, the structure of the isolated compounds was determined using various spectroscopic techniques, including UV, IR, HRTOFMS, 1D, and 2D NMR. The cytotoxic effects of each compound were then evaluated against breast cancer cells of the Michigan Cancer Foundation-7 (MCF-7), but no significant activity was observed.
ISSN:1307-6167
DOI:10.25135/rnp.451.2311.2960