Nationwide trends and outcomes associated with neoadjuvant therapy in pancreatic cancer: An analysis of 18243 patients

• Published in: Journal of surgical oncology Vol. 116; no. 2; p. 127
• Main Authors: Youngwirth, Linda M, Nussbaum, Daniel P, Thomas, Samantha, Adam, Mohamed A, Blazer, Dan G, Roman, Sanziana A, Sosa, Julie A
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc 01.08.2017
• Subjects: Biopsy; Cancer surgery; Cancer therapies; Pancreatic cancer
• ISSN: 0022-4790; 1096-9098
• DOI: 10.1002/jso.24630

Background Neoadjuvant therapy has theoretical benefits for pancreatic cancer; however, its association with perioperative outcomes remains controversial. This study sought to evaluate variation in use of neoadjuvant therapy and outcomes following pancreatic resection. Methods The National Cancer Data Base (1998-2011) was queried for patients with Stage I or II pancreatic adenocarcinoma who underwent pancreaticoduodenectomy. Subjects were classified by use of neoadjuvant chemotherapy and/or radiation therapy. Factors associated with use of neoadjuvant therapy were evaluated, and outcomes were compared. Results A 18243 patients were identified; 1375 (7.5%) received neoadjuvant therapy. From 1998 to 2011, use of neoadjuvant therapy increased from 4.3% to 17.0%. Patients receiving neoadjuvant therapy were younger (63.1 vs 66.1 years, P=0.001) and more likely to receive treatment at an academic facility (64.4% vs 51.4%, P<0.001). Patients who received neoadjuvant therapy were more likely to have negative margins (77.8% vs 85.5%), negative lymph nodes (42.9% vs 59.3%) and tumors confined to the pancreas (65.8% vs 70.6%, all P<0.001). Patients receiving neoadjuvant therapy had lower 30-day mortality (2.0% vs 4.6%, P<0.001) and readmission rates (7.4% vs 9.5%, P=0.02). Conclusions Neoadjuvant therapy use is increasing and associated with comparable short-term outcomes. Further studies are needed to identify patients who would benefit from neoadjuvant therapy.