Rhodamine based turn-on chemosensor for Fe3+ in aqueous medium and interactions of its Fe3+ complex with DNA

A novel di-coordinating rhodamine-based chemosensor, HL with NO donor atoms, selectively and rapidly recognizes Fe3+ in the presence of all biologically relevant as well as toxic metal ions and numerous anions and also with other reactive oxygen and nitrogen species. It exhibits a lower detection li...

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Bibliographic Details
Published inNew journal of chemistry Vol. 42; no. 5; pp. 3435 - 3443
Main Authors Bhowmick, Rahul, Islam, Abu Saleh Musha, Saha, Urmila, Kumar, Gopinatha Suresh, Ali, Mahammad
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 07.03.2018
Royal Society of Chemistry
Subjects
Binding
Chemical sensors
Chemistry
Chemistry, Multidisciplinary
Chemoreceptors
Composite materials
Deoxyribonucleic acid
Dichroism
DNA
Fluorescence
Photonics
Physical Sciences
Rhodamine
Science & Technology
IRON-METABOLISM
SMALL MOLECULES
HIGH SELECTIVITY
SENSOR
IONS
B-DNA
III-AMPLIFIED FLUORESCENCE
BINDING
LIVING CELLS
MINOR-GROOVE
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Summary:A novel di-coordinating rhodamine-based chemosensor, HL with NO donor atoms, selectively and rapidly recognizes Fe3+ in the presence of all biologically relevant as well as toxic metal ions and numerous anions and also with other reactive oxygen and nitrogen species. It exhibits a lower detection limit (0.17 M) and comparatively higher formation constant (K-f = 1.72 x 10(4) M-1). The DNA-binding properties of [LFe(NO3)(2)](+) complex have been comprehensively studied by using UV-Vis, fluorescence, and optical melting studies and circular dichroism, which clearly indicate that [LFe(NO3)(2)](+) interacts with DNA via a groove binding mode. In particular, competition experiments with Hoechst and DAPI constitute firm evidence for this binding mode, and clearly rule out intercalation. The negative G(0) and positive S-0 values obtained from a calorimetric technique confirm the spontaneity of the binding of [LFe(NO3)(2)](+) with DNA. The resulting [LFe(NO3)(2)](+)/DNA composite material could be a valuable candidate for future photonics and/or biological applications.
ISSN:1144-0546
1369-9261
DOI:10.1039/c7nj04505k