The Role of High-Fructose Diet in Liver Function of Rodent Models: A Systematic Review of Molecular Analysis

The present systematic review of animal studies on long-term fructose intake in rodents revealed a significant decrease in the activities of antioxidant enzymes due to a fructose-rich diet. The reduced activity of these enzymes led to an increase in oxidative stress, which can cause liver damage in...

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Bibliographic Details
Published inIranian biomedical journal Vol. 27; no. 6; p. 326
Main Authors Mirzaei, Roya, Khosrokhavar, Roya, Sepideh Arbabi Bidgoli
Format Journal Article
LanguageEnglish
Published Tehran Pasteur Institute of Iran 01.11.2023
Subjects
Animal models
Corn syrup
Diet
Enzymes
Fatty acids
Females
Fructose
Injuries
Liver
Liver diseases
Medical Subject Headings-MeSH
Metabolism
Mitochondrial DNA
Nutrition research
Oxidative stress
Pharmaceutical sciences
Pharmacy
Processed foods
Proteins
Public health
Rodents
Systematic review
Toxicity
Toxicology
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Summary:The present systematic review of animal studies on long-term fructose intake in rodents revealed a significant decrease in the activities of antioxidant enzymes due to a fructose-rich diet. The reduced activity of these enzymes led to an increase in oxidative stress, which can cause liver damage in rodents. Of eight studies analyzed, 5 (62.5%) and 1 (12.5%) used male and female rats, respectively, while 2 studies (25%) used female mice. Moreover, half of the studies used high-fructose corn syrup, but the other half employed fructose in the diet. Hence, it is essential to monitor dietary habits to ensure public health and nutrition research outcomes.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
content type line 14
ObjectType-Feature-3
ObjectType-Evidence Based Healthcare-1
ISSN:1028-852X
2008-823X
DOI:10.61186/ibj.27.6.326