Challenges in the control and treatment of yellow fever in Brazil

• Published in: Acta paulista de enfermagem Vol. 31; no. 2; pp. III - VI
• Main Author: Medeiros, Eduardo Alexandrino Servolo
• Format: Journal Article
• Language: English
• Published: Sao Paulo Universidade Federal de São Paulo, Escola Paulista de Enfermagem 01.03.2018
• Subjects: Amino acids; Animal models; Antiviral drugs; Disease; Disease prevention; DNA-directed RNA polymerase; Epidemics; Epidemiology; Fever; Hepatocytes; Immunoglobulins; Liver; Monkeys & apes; Mortality; Mosquitoes; Nosocomial infections; Population density; Public health; Ribonucleic acid; RNA; Transplants & implants; Vaccines; Vector-borne diseases; Viruses; Brazil; Rio de Janeiro Brazil
• ISSN: 0103-2100; 1982-0194
• DOI: 10.1590/1982-0194201800017

According to the dates and locations of the monkey deaths was constructed an epidemiological model that describes the direction, speed, and likely pathways of the spread of the disease. (3) demonstrated, in vitro, that sofosbuvir binds to conserved amino acid residues in the NS5 RNA-dependent RNA-polymerase of the yellow fever virus, inhibiting viral replication in human hepatocytes and decreasing mortality in animal models. The World Health Organization recommends administering a standard dose of the vaccine, stating that the standard dose is sufficient to ensure immunity and lifelong protection for travelers to endemic areas. (5) With the advance of the epidemic to areas of high population density in Brazil, a large number of doses were required and were not available in the short term. [...]the use of a fractional dose was adopted as an alternative means of containing the epidemic.