Swollen axons impair neuronal circuits

Because the brains of people in the advanced stages of the disease contain more than 20 plaques per square millimetre (ref. 4), axonal conduction abnormalities might be an important mechanism for neural-network dysfunction in Alzheimer's disease. Yuan and colleagues found that unusually large e...

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Bibliographic Details
Published inNature (London) Vol. 612; no. 7939; pp. 1 - 2
Main Authors Cobos, Inma, Palop, Jorge J
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group 08.12.2022
Subjects
Ablation
Abnormalities
Alzheimer's disease
Animal cognition
Axons
Brain
Health risks
Neural networks
Neurodegenerative diseases
Neurons
Organelles
Plaques
Proteins
United States > US
San Francisco California
California
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Summary:Because the brains of people in the advanced stages of the disease contain more than 20 plaques per square millimetre (ref. 4), axonal conduction abnormalities might be an important mechanism for neural-network dysfunction in Alzheimer's disease. Yuan and colleagues found that unusually large endolysosomal vesicles were more abundant in dystrophic neurites of people with Alzheimer's disease who carried the V232M variant than in those of non-carriers, suggesting that altered endolysosomal function promotes dystrophic neurites, which might increase the risk of Alzheimer's disease. Furthermore, it remains unclear exactly how PLD3 variants increase the risk of Alzheimer's disease and promote accumulation of organelles in dystrophic neurites. [...]this knowledge gap is filled, it is premature to propose PLD3-based interventions as potential therapies.
ISSN:0028-0836
1476-4687
DOI:10.1038/d41586-022-03800-7