NON-LINEAR AND LINEARIZED IVIV CORRELATIONS FOR TABLETS CONTAINING A LARGE MOLECULE POLAR COMPOUND

[...]class III drugs exhibit a high variability of rate and extent of absorbed drug. Since the dissolution is immediate, the variation is due to alteration of gastrointestinal (GI) physiological properties and membrane permeation rather than dosage form factors. 2.MATERIALS AND METHODS 2.1. Fitting...

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Published inJournal of the sciences and arts Vol. 18; no. 1; pp. 203 - 210
Main Authors Mircioiu, Ion, Anuta, Valentina, Stanciu, Gabriela, Sirbu, Rodica, Sandulovici, Roxana
Format Journal Article
LanguageEnglish
Published Targoviste Valahia State University under the authority of The National University Research Council 01.01.2018
Subjects
Drug dosages
Experiments
Pharmaceuticals
Physiology
Psoriasis
Rheumatoid arthritis
Tablets
Toxicology
Germany
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ISSN1844-9581
2068-3049

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Summary:[...]class III drugs exhibit a high variability of rate and extent of absorbed drug. Since the dissolution is immediate, the variation is due to alteration of gastrointestinal (GI) physiological properties and membrane permeation rather than dosage form factors. 2.MATERIALS AND METHODS 2.1. Fitting data with solutions of compartmental models lead to good approximations of theoretical curves. Since fitting improvement by bicompartmental modeling was not significant (as proved by Akaike index and comparison of residual sum of squares by Fisher test) monocompartmental model was preferred (Fig. 5) [13, 14]. [...]the absorbed fraction of drug (FRA) at the moment would be given by formulas ... where c is the plasma concentration, Vd volume of central compartment, ke elimination constant. [...]a linear correlation between FRA and FRD can be obtained in case of lipophilic drugs, when release is slow and absorption is rapid.
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ISSN:1844-9581
2068-3049