Direct chromosome analysis in the second and third trimesters by placental biopsy in 30 pregnancies

Direct chromosome analysis was performed on placental villi obtained by ultrasound-guided transabdominal needle aspiration in 30 women at between 23 and 37 weeks gestation. Placental biopsy is simple in the presence of severe oligohydramnios where fetal blood sampling is usually more difficult. Dire...

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Bibliographic Details
Published inBritish journal of obstetrics and gynaecology Vol. 96; no. 10; p. 1215
Main Authors Saura, R, Longy, M, Horovitz, J, Vergnaud, A, Grison, O
Format Journal Article
LanguageEnglish
Published England 01.10.1989
Subjects
Adult
Chorionic Villi Sampling
Chromosome Aberrations - diagnosis
Chromosome Aberrations - genetics
Chromosome Disorders
Congenital Abnormalities - genetics
Female
Fetal Diseases - diagnosis
Fetal Diseases - genetics
Humans
Karyotyping - methods
Pregnancy
Pregnancy Trimester, Second
Pregnancy Trimester, Third
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Summary:Direct chromosome analysis was performed on placental villi obtained by ultrasound-guided transabdominal needle aspiration in 30 women at between 23 and 37 weeks gestation. Placental biopsy is simple in the presence of severe oligohydramnios where fetal blood sampling is usually more difficult. Direct karyotyping of placental villi is more rapid than chromosomal analysis from fetal blood and from amniotic fluid. Two chromosomal anomalies were discovered: one trisomy 18 and one 6p+. Villus sampling failed in one woman and two samples obtained at 36 and 37 weeks gestation could not be karyotyped. The procedure did not affect the outcome of the pregnancy.
ISSN:0306-5456