Chromosome localization of the human oncogene INT1 to 12q13 by in situ hybridization

The human oncogene INT1 has been mapped to chromosome band 12q13 by in situ hybridization. The precise localization of this gene is of particular interest, since the region 12q13---q14 has been reported to be involved in chromosomal rearrangements in lipomas, myxoid liposarcomas, pleomorphic adenoma...

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Bibliographic Details
Published inCytogenetics and cell genetics Vol. 47; no. 1-2; p. 86
Main Authors Arheden, K, Mandahl, N, Strömbeck, B, Isaksson, M, Mitelman, F
Format Journal Article
LanguageEnglish
Published Switzerland 1988
Subjects
Chromosome Mapping
Chromosomes, Human, Pair 12 - ultrastructure
Humans
Neoplasms - genetics
Nucleic Acid Hybridization
Oncogenes
Proto-Oncogene Proteins - genetics
Wnt Proteins
Wnt1 Protein
Zebrafish Proteins
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Summary:The human oncogene INT1 has been mapped to chromosome band 12q13 by in situ hybridization. The precise localization of this gene is of particular interest, since the region 12q13---q14 has been reported to be involved in chromosomal rearrangements in lipomas, myxoid liposarcomas, pleomorphic adenomas, and myomas. The involvement of this region in both benign and malignant tumors suggests a common pathogenetic pathway in which changes affecting INT1 may be an important step.
ISSN:0301-0171