Molecular Origins of Cancer: Molecular Basis of Metastasis

Metastases are the principal cause of death in patients with cancer. Recent advances bring hope that it will be possible to identify the molecules and processes involved in metastasis, and this new knowledge could lead to effective methods of preventing and treating metastases. This review describes...

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Bibliographic Details
Published inThe New England journal of medicine Vol. 359; no. 26; p. 2814
Main Authors Chiang, Anne C, Massagué, Joan
Format Journal Article
LanguageEnglish
Published Boston Massachusetts Medical Society 25.12.2008
Subjects
Breast cancer
Chemokines
Deoxyribonucleic acid
DNA
DNA damage
Gene expression
Hypoxia
Kinases
Ligands
Proteins
Tumors
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Summary:Metastases are the principal cause of death in patients with cancer. Recent advances bring hope that it will be possible to identify the molecules and processes involved in metastasis, and this new knowledge could lead to effective methods of preventing and treating metastases. This review describes the properties of cells that enable them to surmount physical boundaries, disseminate, and colonize a distant organ.
Bibliography:SourceType-Scholarly Journals-1
ObjectType-General Information-1
content type line 14
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMra0805239