Distribution of arylamine N-acetyltransferase 2 (nat2) genotypes among Omanis

• Published in: Journal for scientific research. Medical sciences Vol. 5; no. 1-2; pp. 9 - 14
• Main Authors: Tanira, Musbah O M, Simsek, Mehmet, Al Balushi, Khalid, Al Lawatia, Khulood, Al Barawani, Hameedah, Bayoumi, Riad A
• Format: Journal Article
• Language: English
• Published: Oman Sultan Qaboos University Medical Journal, College of Medicine & Health Sciences 01.08.2003
• Subjects: N-acetyltransferase (NAT2); Omani; genotyping
• ISSN: 1029-4066; 1729-9810

to determine the genotypes of arylamine N-acetyltransferase (NAT2) among 127 unrelated apparently healthy Omanis. Identify the most common known polymorphisms of NAT*2 gene namely, G(191)A, C(282)T, C(341)T, C(481)T, G(590)A, A(803)G and G(857)A using PCR-RFLP analysis. Eleven allele variants (3 alternative) and 30 different genotypes were determined. The commonest alleles were found to be NAT*5B, NAT2*6A and NAT*4 with corresponding frequencies of 0.362, 0.248 and 0.189 respectively. The overall frequency of rapid acetylator alleles was 0.25. A new allele variant containing G(590)A, C(282)T and T(341)C polymorphisms was found in one subject (was named NAT2*5J). The commonest genotypes were found to be 5B/5B, 5B/6A, 4/5B, 4/6A with frequencies 0.165, 0.157, 0.118, 0.110 and 0.079 respectively.