(2S,3R,4S,4aR)-2,3,4,7-Tetra-hydroxy-3,4,4a,5-tetra-hydro-[1,3]dioxolo[4,5-j]phenanthridin-6(2H)-one hemihydrate

• Published in: Acta crystallographica. Section E, Structure reports online Vol. 69; no. Pt 1; pp. o9 - o10
• Main Authors: Jucov, Evgheni, Kornienko, Alexander, Masi, Marco, Evidente, Antonio, Antipin, Mikhail
• Format: Journal Article
• Language: English
• Published: United States International Union of Crystallography 01.01.2013
• Subjects: Organic Papers
• ISSN: 1600-5368; 1600-5368
• DOI: 10.1107/S1600536812048763

The title natural compound, isolated from Narcissus pseudonarcissus var. King Alfred crystallizes as a hemihydrate, C14H13NO7·0.5H2O, with four crystallographically independent dioxolophenanthridinone mol-ecules and two crystallographically independent solvent water mol-ecules in the asymmetric unit. All four crystallographically independent dioxolophenanthridinone mol-ecules are geometrically very similar and differ only in the orientations of the three hy-droxy groups at the terminal cyclo-hexene rings. The five-membered dioxolane ring has a planar conformation (the r.m.s. deviations are 0.010, 0.019, 0.025 and 0.004 Å, for the four crystallographically independent molecules), and the six-membered dihydro-pyridone and cyclo-hexene rings adopt sofa conformations in each mol-ecule. The flattened structure of each dioxolophenanthridinone mol-ecule is supported by a strong intra-molecular O-H⋯O hydrogen bond. The N atom has a slightly pyramidalized configuration. In the crystal, the dioxolophenanthridinone mol-ecules form layers parallel to (101) with O-H⋯O and N-H⋯O hydrogen bonds linking the dioxolophenanthridinone mol-ecules both within and between the layers and the water mol-ecules, forming a three-dimensional framework. The absolute configurations of the chiral centers are 2S, 3R, 4S and 4aR.