Anti-cancerous triterpenoid saponins from Lecaniodiscus cupanioides
From the ethanol extract of the stem of Planch, two known compounds and were isolated and identified as triterpenoid saponins 3-O-[α-L-arabinofuranosyl- (1→3)-α-L-rhamnopyranosyl- (1→2)-α-L-arabinopyranosyl-]-hederagenin and 3-O- [α-L-arabinopyranosyl- (1→3)-α-L-rhamnopyranosyl (1→2)-α-L-arabinopyra...
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Published in | Journal of natural products (Gorakhpur) Vol. 7; p. 155 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
India
2014
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Subjects | |
Online Access | Get more information |
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Summary: | From the ethanol extract of the stem of
Planch, two known compounds
and
were isolated and identified as triterpenoid saponins 3-O-[α-L-arabinofuranosyl- (1→3)-α-L-rhamnopyranosyl- (1→2)-α-L-arabinopyranosyl-]-hederagenin and 3-O- [α-L-arabinopyranosyl- (1→3)-α-L-rhamnopyranosyl (1→2)-α-L-arabinopyranosyl-]-hederagenin. The structures were established by physicochemical and spectroscopic investigations (MS and NMR) as well as comparison of literature data. The compound
exhibited anticancer activity against human colon carcinoma H-116, human lung carcinoma A-549 and human lung carcinoma HT-29 cell lines with IC
5.0, 2.5 and 2.5μg/ml respectively and compound
exhibited similar activities with IC
5.0, 5.0 and 2.5μg/ml respectively. This suggests that the isolated triterpenoid saponins may be considered as potential anticancer leads for further studies. |
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ISSN: | 0974-5211 0974-5211 |